CMap Candidate Details

Structure:
CMap ID: C06373
Pert ID: BRD-K12765235
Compound Name: carbenoxolone
Targets: HSD11B1
MoA: 11-beta-HSD1 inhibitor
SMILES: CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@]43C)C(=O)O)OC(=O)CCC(=O)O
InchiKey: OBZHEBDUNPOCJG-WBXJDKIVSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4547 BRD-K12765235 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4777 BRD-K12765235 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5036 BRD-K12765235 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.96 0.44
44306 BRD-K12765235 A375 10 uM 6 h -0.2 -0.82 0.0 0.0 0.0 0.0
44673 BRD-K12765235 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44859 BRD-K12765235 ASC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.38
45164 BRD-K12765235 HEPG2 10 uM 6 h 0.25 1.04 0.15 0.0 0.0 0.0
45432 BRD-K12765235 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45774 BRD-K12765235 MCF??7.00 10 uM 6 h -0.32 -1.34 0.98 0.35 1.24 1.25
45974 BRD-K12765235 NPC 10 uM 24 h -0.28 -1.18 0.5 -0.34 -1.16 1.11
46294 BRD-K12765235 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46609 BRD-K12765235 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).