CMap Candidate Details

Structure:
CMap ID: C00639
Pert ID: BRD-A25234499
Compound Name: aminoglutethimide
Targets: CYP11A1; CYP19A1
MoA: Glucocorticoid receptor antagonist
SMILES: CCC1(CCC(=O)NC1=O)c1ccc(N)cc1
InchiKey: ROBVIMPUHSLWNV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
19863 BRD-A25234499 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
20189 BRD-A25234499 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
20997 BRD-A25234499 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
21677 BRD-A25234499 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.17 1.11
37461 BRD-A25234499 ASC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
38311 BRD-A25234499 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38612 BRD-A25234499 PHH 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.37 2.02
38835 BRD-A25234499 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91348 BRD-A25234499 HUH7 15 uM 72 h 0.21 0.87 0.01 0.41 1.45 2.22
119967 BRD-A25234499 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120014 BRD-A25234499 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
120082 BRD-A25234499 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120170 BRD-A25234499 PC3 1.11 uM 24 h 0.2 0.85 0.01 0.0 0.0 0.0
128788 BRD-A25234499 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128823 BRD-A25234499 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128855 BRD-A25234499 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).