CMap Candidate Details

Structure:
CMap ID: C00064
Pert ID: BRD-A02481876
Compound Name: importazole
Targets: KPNB1
MoA: Importin-beta transport receptor inhibitor
SMILES: CC(Nc1nc(nc2ccccc12)N3CCCC3)c4ccccc4
InchiKey: HKGJEZIGDHFJFL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9261 BRD-A02481876 AGS 60 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9564 BRD-A02481876 H1299 60 uM 6 h 0.0 0.0 0.0 0.25 0.9 0.22
9997 BRD-A02481876 HA1E 60 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10378 BRD-A02481876 HCT116 60 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10646 BRD-A02481876 HEPG2 60 uM 6 h -0.22 -0.92 0.06 0.0 0.0 0.0
11068 BRD-A02481876 HT29 60 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11244 BRD-A02481876 MCF??7.00 60 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11314 BRD-A02481876 NCIH2073 60 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11634 BRD-A02481876 NCIH508 60 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11885 BRD-A02481876 NCIH596 60 uM 6 h 0.27 1.11 0.26 -0.33 -1.1 0.86
12573 BRD-A02481876 PC3 60 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12640 BRD-A02481876 SW480 60 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13123 BRD-A02481876 U937 60 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13411 BRD-A02481876 VCAP 60 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90551 BRD-A02481876 A549 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
96032 BRD-A02481876 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
114941 BRD-A02481876 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
118403 BRD-A02481876 A375 10 uM 24 h 0.18 0.76 0.0 0.4 1.42 2.19
118515 BRD-A02481876 HCC515 10 uM 24 h -0.28 -1.18 0.5 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).