CMap Candidate Details

Structure:
CMap ID: C06415
Pert ID: BRD-K12885236
Compound Name: dapivirine
Targets: CYP3A4; CYP3A5
MoA: Non-nucleoside reverse transcriptase inhibitor
SMILES: Cc1cc(C)c(Nc2ccnc(Nc3ccc(cc3)C#N)n2)c(C)c1
InchiKey: ILAYIAGXTHKHNT-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122242 BRD-K12885236 A375 10 uM 24 h -0.15 -0.62 0.0 0.0 0.0 0.0
122295 BRD-K12885236 HA1E 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
122409 BRD-K12885236 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.49
122434 BRD-K12885236 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122464 BRD-K12885236 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122512 BRD-K12885236 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.43 -1.43 15.35
130549 BRD-K12885236 A549 0.74 uM 24 h 0.25 1.03 0.14 0.31 1.11 0.72
130616 BRD-K12885236 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130657 BRD-K12885236 HELA 2.22 uM 24 h 0.17 0.72 0.0 0.0 0.0 0.0
130699 BRD-K12885236 HT29 0.74 uM 24 h -0.16 -0.67 0.0 0.0 0.0 0.0
130736 BRD-K12885236 MCF10A 0.01 uM 24 h -0.3 -1.23 0.64 0.34 1.2 1.13
130757 BRD-K12885236 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).