CMap Candidate Details

Structure:
CMap ID: C00644
Pert ID: BRD-A25569250
Compound Name: KI-16425
Targets: LPAR1; LPAR3
MoA: Lysophosphatidic acid receptor antagonist
SMILES: CC(OC(=O)Nc1c(C)noc1-c1ccc(CSCCC(O)=O)cc1)c1ccccc1Cl
InchiKey: LLIFMNUXGDHTRO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29716 BRD-A25569250 A375 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.98 0.49
30134 BRD-A25569250 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30290 BRD-A25569250 ASC 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.2
30618 BRD-A25569250 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30902 BRD-A25569250 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31197 BRD-A25569250 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31652 BRD-A25569250 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31798 BRD-A25569250 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
32099 BRD-A25569250 NEU 10 uM 24 h 0.24 0.99 0.1 -0.22 -0.73 0.05
32284 BRD-A25569250 NPC 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
32580 BRD-A25569250 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32880 BRD-A25569250 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33399 BRD-A25569250 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).