CMap Candidate Details

Structure:
CMap ID: C06454
Pert ID: BRD-K12994359
Compound Name: valdecoxib
Targets: PTGS2
MoA: Cyclooxygenase inhibitor
SMILES: Cc1onc(c1-c1ccc(cc1)S(N)(=O)=O)-c1ccccc1
InchiKey: LNPDTQAFDNKSHK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8914 BRD-K12994359 A375 200 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9181 BRD-K12994359 A549 200 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.8
9367 BRD-K12994359 AGS 200 uM 6 h 0.0 0.0 0.0 -0.25 -0.84 0.18
9673 BRD-K12994359 H1299 200 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10034 BRD-K12994359 HA1E 200 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10166 BRD-K12994359 HCC515 200 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
10465 BRD-K12994359 HCT116 200 uM 6 h -0.28 -1.18 0.51 -0.38 -1.28 1.45
10738 BRD-K12994359 HEPG2 200 uM 6 h -0.28 -1.18 0.5 -0.44 -1.48 15.35
10948 BRD-K12994359 HT29 200 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11173 BRD-K12994359 MCF??7.00 200 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11426 BRD-K12994359 NCIH2073 200 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11717 BRD-K12994359 NCIH508 200 uM 6 h 0.0 0.0 0.0 -0.3 -0.99 0.51
11993 BRD-K12994359 NCIH596 200 uM 6 h 0.0 0.0 0.0 0.33 1.15 0.9
12488 BRD-K12994359 PC3 200 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12738 BRD-K12994359 SW480 200 uM 6 h 0.0 0.0 0.0 -0.27 -0.91 0.3
13217 BRD-K12994359 U937 200 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13586 BRD-K12994359 VCAP 200 uM 6 h 0.0 0.0 0.0 -0.28 -0.96 0.43
95990 BRD-K12994359 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100099 BRD-K12994359 U2OS 10 uM 6 h 0.0 0.0 0.0 0.27 0.94 0.3
122413 BRD-K12994359 MDAMB231 0.125 uM 24 h 0.25 1.06 0.19 0.0 0.0 0.0
122469 BRD-K12994359 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130620 BRD-K12994359 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130661 BRD-K12994359 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130738 BRD-K12994359 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130831 BRD-K12994359 YAPC 0.03 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).