CMap Candidate Details

Structure:
CMap ID: C00648
Pert ID: BRD-A25736793
Compound Name: everolimus
Targets: MTOR
MoA: MTOR inhibitor
SMILES: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC
InchiKey: HKVAMNSJSFKALM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92874 BRD-A25736793 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92901 BRD-A25736793 A549 0.12 uM 24 h -0.25 -1.05 0.23 -0.38 -1.29 1.57
92940 BRD-A25736793 ASC 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.23 1.25
93007 BRD-A25736793 CD34 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.7
93047 BRD-A25736793 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93094 BRD-A25736793 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.24
93135 BRD-A25736793 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93179 BRD-A25736793 HEPG2 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93233 BRD-A25736793 HUVEC 0.12 uM 24 h 0.26 1.1 0.24 -0.35 -1.18 1.14
93286 BRD-A25736793 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93322 BRD-A25736793 MCF10A 10 uM 24 h -0.3 -1.24 0.64 -0.32 -1.07 0.77
93366 BRD-A25736793 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 -0.41 -1.39 2.02
93400 BRD-A25736793 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93453 BRD-A25736793 PC3 0.12 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.09
93492 BRD-A25736793 SKL 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93551 BRD-A25736793 THP1 10 uM 24 h -0.29 -1.22 0.61 -0.27 -0.89 0.27
93591 BRD-A25736793 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).