CMap Candidate Details

Structure:
CMap ID: C00649
Pert ID: BRD-A25775766
Compound Name: securinine
Targets: GABRA1
MoA: TP53 activator; GABA receptor antagonist
SMILES: O=C1OC2(C[C@H]3C=CC2=C1)[C@H]4CCCCN34
InchiKey: SWZMSZQQJRKFBP-KKPNGEORSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4009 BRD-A25775766 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4286 BRD-A25775766 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
4612 BRD-A25775766 PC3 10 uM 24 h -0.2 -0.85 0.01 0.24 0.85 0.15
4985 BRD-A25775766 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37053 BRD-A25775766 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37331 BRD-A25775766 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37462 BRD-A25775766 ASC 10 uM 24 h 0.0 0.0 0.0 0.2 0.7 0.01
37796 BRD-A25775766 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37991 BRD-A25775766 HT29 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.9
38136 BRD-A25775766 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
38312 BRD-A25775766 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38613 BRD-A25775766 PHH 10 uM 24 h 0.23 0.97 0.08 -0.24 -0.81 0.13
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).