CMap Candidate Details

Structure:
CMap ID: C06518
Pert ID: BRD-K13154216
Compound Name: everolimus
Targets: MTOR
MoA: MTOR inhibitor
SMILES: CO[C@@H]1C[C@H](C[C@H](C)[C@@H]2CC(=O)[C@H](C)C=C(C)[C@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=CC=CC=C(C)[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1OCCO
InchiKey: HKVAMNSJSFKALM-MUKRYTAKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95467 BRD-K13154216 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
122250 BRD-K13154216 A375 1.11 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
122284 BRD-K13154216 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122360 BRD-K13154216 MCF10A 10 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
122417 BRD-K13154216 MDAMB231 3.33 uM 24 h -0.18 -0.74 0.0 0.0 0.0 0.0
122439 BRD-K13154216 PC3 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
122473 BRD-K13154216 THP1 10 uM 24 h -0.24 -0.99 0.13 -0.32 -1.07 0.78
122515 BRD-K13154216 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130588 BRD-K13154216 HA1E 0.01 uM 24 h 0.22 0.91 0.04 -0.25 -0.86 0.2
130624 BRD-K13154216 HEK293 2.22 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.34
130665 BRD-K13154216 HELA 0.74 uM 24 h -0.25 -1.04 0.22 0.0 0.0 0.0
130705 BRD-K13154216 HT29 2.22 uM 24 h 0.25 1.04 0.14 0.0 0.0 0.0
130760 BRD-K13154216 MCF??7.00 0.01 uM 24 h 0.19 0.77 0.0 -0.36 -1.23 1.25
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).