CMap Candidate Details

Structure:
CMap ID: C06626
Pert ID: BRD-K13533483
Compound Name: cyclosporin-a
Targets: PPIA; PPP3CA
MoA: Calcineurin inhibitor
SMILES: CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C/C=C/C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InchiKey: PMATZTZNYRCHOR-FVTPFZBWSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1552 BRD-K13533483 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1891 BRD-K13533483 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2275 BRD-K13533483 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2613 BRD-K13533483 VCAP 10 uM 24 h -0.32 -1.34 0.98 -0.3 -1.01 0.58
41730 BRD-K13533483 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42064 BRD-K13533483 A549 10 uM 6 h 0.0 0.0 0.0 0.29 1.01 0.45
42304 BRD-K13533483 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42939 BRD-K13533483 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43296 BRD-K13533483 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43496 BRD-K13533483 NPC 10 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
43798 BRD-K13533483 PHH 10 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.07
52955 BRD-K13533483 HEPG2 20 uM 3 h 0.0 0.0 0.0 0.23 0.8 0.08
53293 BRD-K13533483 MCF10A 100 uM 24 h -0.16 -0.67 0.0 -0.33 -1.12 0.94
100106 BRD-K13533483 U2OS 1.67 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).