CMap Candidate Details

Structure:
CMap ID: C00666
Pert ID: BRD-A26334849
Compound Name: propafenone
Targets: KCNH2; SCN5A
MoA: Antiarrhythmic
SMILES: CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1
InchiKey: JWHAUXFOSRPERK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4288 BRD-A26334849 HCC515 10 uM 24 h -0.3 -1.25 0.7 -0.25 -0.84 0.17
4843 BRD-A26334849 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37332 BRD-A26334849 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37465 BRD-A26334849 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38137 BRD-A26334849 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38315 BRD-A26334849 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90979 BRD-A26334849 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
119935 BRD-A26334849 A375 10 uM 24 h 0.28 1.16 0.36 0.0 0.0 0.0
120018 BRD-A26334849 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120043 BRD-A26334849 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120090 BRD-A26334849 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120208 BRD-A26334849 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
128841 BRD-A26334849 PC3 0.01 uM 24 h 0.26 1.08 0.22 -0.23 -0.78 0.1
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).