CMap Candidate Details

Structure:
CMap ID: C06750
Pert ID: BRD-K13926615
Compound Name: vardenafil
Targets: PDE5A
MoA: Phosphodiesterase inhibitor
SMILES: CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1
InchiKey: SECKRCOLJRRGGV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4367 BRD-K13926615 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4898 BRD-K13926615 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
22989 BRD-K13926615 HEPG2 10 uM 6 h 0.21 0.89 0.02 -0.29 -0.97 0.47
37599 BRD-K13926615 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38432 BRD-K13926615 NPC 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
91084 BRD-K13926615 HUH7 6.66 uM 72 h 0.0 0.0 0.0 -0.26 -0.87 0.22
96716 BRD-K13926615 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122344 BRD-K13926615 HT29 0.04 uM 24 h -0.24 -1.0 0.15 -0.26 -0.88 0.24
122390 BRD-K13926615 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
122420 BRD-K13926615 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122478 BRD-K13926615 THP1 10 uM 24 h -0.24 -1.01 0.15 0.0 0.0 0.0
130558 BRD-K13926615 A549 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130593 BRD-K13926615 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130627 BRD-K13926615 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130670 BRD-K13926615 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130741 BRD-K13926615 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130814 BRD-K13926615 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
130839 BRD-K13926615 YAPC 0.08 uM 24 h -0.28 -1.15 0.44 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).