CMap Candidate Details

Structure:
CMap ID: C00680
Pert ID: BRD-A26845397
Compound Name: isamoltane
Targets: HTR1A; HTR1B
MoA: Adrenergic receptor antagonist
SMILES: CC(C)NCC(O)COc1ccccc1-n1cccc1
InchiKey: XVTVPGKWYHWYAD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1685 BRD-A26845397 HA1E 10 uM 6 h 0.17 0.69 0.0 0.36 1.29 1.49
2033 BRD-A26845397 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2326 BRD-A26845397 PC3 10 uM 6 h -0.21 -0.87 0.02 -0.31 -1.05 0.7
2740 BRD-A26845397 VCAP 10 uM 6 h -0.25 -1.05 0.23 -0.35 -1.16 1.11
41656 BRD-A26845397 A375 10 uM 6 h 0.2 0.82 0.0 0.0 0.0 0.0
42004 BRD-A26845397 A549 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.03 0.64
42191 BRD-A26845397 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42535 BRD-A26845397 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.0 0.55
42842 BRD-A26845397 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43118 BRD-A26845397 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43391 BRD-A26845397 NPC 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
43705 BRD-A26845397 PHH 10 uM 24 h -0.26 -1.07 0.26 -0.34 -1.14 1.03
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).