CMap Candidate Details

Structure:
CMap ID: C06880
Pert ID: BRD-K14282469
Compound Name: LY-165163
Targets: HTR1A; HTR1D
MoA: Serotonin receptor antagonist
SMILES: Nc1ccc(CCN2CCN(CC2)c3cccc(c3)C(F)(F)F)cc1
InchiKey: GAAKALASJNGQKD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1555 BRD-K14282469 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1893 BRD-K14282469 HCC515 10 uM 24 h 0.0 0.0 0.0 0.21 0.76 0.05
2240 BRD-K14282469 PC3 10 uM 24 h -0.28 -1.18 0.51 -0.24 -0.79 0.11
2559 BRD-K14282469 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41732 BRD-K14282469 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42066 BRD-K14282469 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42307 BRD-K14282469 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42638 BRD-K14282469 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42942 BRD-K14282469 HT29 10 uM 6 h 0.26 1.08 0.2 0.0 0.0 0.0
43162 BRD-K14282469 MCF??7.00 10 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
43499 BRD-K14282469 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43801 BRD-K14282469 PHH 10 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.68
98477 BRD-K14282469 NEU 10 uM 6 h 0.25 1.02 0.13 0.32 1.13 0.83
100114 BRD-K14282469 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).