CMap Candidate Details

Structure:
CMap ID: C07003
Pert ID: BRD-K14653796
Compound Name: tasquinimod
Targets: S100A9; HDAC4
MoA: S100A9 inhibitor; Angiogenesis inhibitor
SMILES: COc1cccc2n(C)c(=O)c(C(=O)N(C)c3ccc(cc3)C(F)(F)F)c(O)c12
InchiKey: ONDYALNGTUAJDX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96659 BRD-K14653796 PC3 1.11 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.49
122263 BRD-K14653796 A375 10 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
122368 BRD-K14653796 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.34
122396 BRD-K14653796 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
122486 BRD-K14653796 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130566 BRD-K14653796 A549 2.22 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
130598 BRD-K14653796 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130633 BRD-K14653796 HEK293 0.74 uM 24 h 0.27 1.13 0.29 0.0 0.0 0.0
130676 BRD-K14653796 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130718 BRD-K14653796 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130791 BRD-K14653796 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130843 BRD-K14653796 YAPC 0.74 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.71
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).