CMap Candidate Details

Structure:
CMap ID: C07058
Pert ID: BRD-K14807180
Compound Name: SB-221284
Targets: HTR2B; HTR2C
MoA: Serotonin receptor antagonist
SMILES: CSc1cc2CCN(C(=O)Nc3cccnc3)c2cc1C(F)(F)F
InchiKey: OQZOXHCRSXYSPM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4065 BRD-K14807180 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4371 BRD-K14807180 HCC515 10 uM 24 h -0.24 -1.01 0.16 0.0 0.0 0.0
4651 BRD-K14807180 PC3 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.29
5040 BRD-K14807180 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.92
44312 BRD-K14807180 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44676 BRD-K14807180 A549 10 uM 6 h -0.26 -1.1 0.34 -0.35 -1.19 1.15
44866 BRD-K14807180 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45170 BRD-K14807180 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45439 BRD-K14807180 HT29 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.82 0.14
45656 BRD-K14807180 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
45981 BRD-K14807180 NPC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.4
46300 BRD-K14807180 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46617 BRD-K14807180 SKB 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
100123 BRD-K14807180 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).