CMap Candidate Details

Structure:
CMap ID: C07080
Pert ID: BRD-K14870255
Compound Name: R-428
Targets: AXL
MoA: AXL kinase inhibitor
SMILES: Nc1nc(Nc2ccc3CC[C@@H](CCc3c2)N2CCCC2)nn1-c1cc2CCCc3ccccc3-c2nn1
InchiKey: KXMZDGSRSGHMMK-VWLOTQADSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
116089 BRD-K14870255 HCC515 10 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.87
116133 BRD-K14870255 HEPG2 0.125 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.26
116180 BRD-K14870255 HT29 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
116219 BRD-K14870255 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116258 BRD-K14870255 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122265 BRD-K14870255 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.2
122287 BRD-K14870255 A549 10 uM 24 h 0.29 1.22 0.48 0.0 0.0 0.0
122322 BRD-K14870255 HEK293 10 uM 24 h 0.23 0.97 0.08 0.27 0.96 0.34
122370 BRD-K14870255 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122423 BRD-K14870255 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122488 BRD-K14870255 THP1 10 uM 24 h -0.27 -1.13 0.4 0.21 0.75 0.04
122523 BRD-K14870255 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130599 BRD-K14870255 HA1E 2.22 uM 24 h 0.27 1.15 0.32 0.0 0.0 0.0
130677 BRD-K14870255 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).