CMap Candidate Details

Structure:
CMap ID: C00710
Pert ID: BRD-A28746609
Compound Name: paclitaxel
Targets: TUBB; NR1I2
MoA: Tubulin inhibitor
SMILES: CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)C3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1
InchiKey: RCINICONZNJXQF-VAZQATRQSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5509 BRD-A28746609 HCC515 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.21
6130 BRD-A28746609 PC3 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.2
6362 BRD-A28746609 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.3 -0.99 0.51
37222 BRD-A28746609 A549 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
37468 BRD-A28746609 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37801 BRD-A28746609 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38318 BRD-A28746609 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38617 BRD-A28746609 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87286 BRD-A28746609 BJAB 0.04 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.19
87362 BRD-A28746609 HBL1 0.04 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
87412 BRD-A28746609 K562 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87460 BRD-A28746609 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87487 BRD-A28746609 MINO 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87564 BRD-A28746609 NALM6 0.01 uM 24 h 0.27 1.14 0.32 0.0 0.0 0.0
87614 BRD-A28746609 OCILY10 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87665 BRD-A28746609 OCILY19 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87716 BRD-A28746609 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87763 BRD-A28746609 SKMEL5 0.04 uM 24 h 0.0 0.0 0.0 -0.47 -1.58 15.65
87820 BRD-A28746609 THP1 10 uM 6 h 0.21 0.88 0.01 0.26 0.93 0.27
87835 BRD-A28746609 TMD8 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90888 BRD-A28746609 MCF10A 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
121961 BRD-A28746609 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
121983 BRD-A28746609 HELA 3.33 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
122055 BRD-A28746609 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130187 BRD-A28746609 A375 0.01 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.88
130233 BRD-A28746609 HA1E 2.22 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
130322 BRD-A28746609 HT29 0.03 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
130356 BRD-A28746609 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130434 BRD-A28746609 MCF??7.00 0.01 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
130454 BRD-A28746609 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130527 BRD-A28746609 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).