CMap Candidate Details

Structure:
CMap ID: C07139
Pert ID: BRD-K15108141
Compound Name: gemcitabine
Targets: RRM1
MoA: Ribonucleotide reductase inhibitor
SMILES: Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)c(=O)n1
InchiKey: SDUQYLNIPVEERB-QPPQHZFASA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8917 BRD-K15108141 A375 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9088 BRD-K15108141 A549 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9371 BRD-K15108141 AGS 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9679 BRD-K15108141 H1299 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10469 BRD-K15108141 HCT116 0.08 uM 6 h 0.0 0.0 0.0 0.27 0.97 0.36
11431 BRD-K15108141 NCIH2073 0.08 uM 6 h 0.31 1.29 0.67 -0.28 -0.96 0.43
11722 BRD-K15108141 NCIH508 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12276 BRD-K15108141 NOMO1 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12742 BRD-K15108141 SW480 0.08 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.9
13107 BRD-K15108141 THP1 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13222 BRD-K15108141 U937 0.08 uM 6 h 0.26 1.09 0.23 -0.36 -1.22 1.25
13452 BRD-K15108141 VCAP 0.08 uM 24 h -0.17 -0.72 0.0 0.0 0.0 0.0
90561 BRD-K15108141 MCF??7.00 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91184 BRD-K15108141 HUH7 12.5 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
115780 BRD-K15108141 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119893 BRD-K15108141 HCC515 0.125 uM 6 h 0.25 1.03 0.13 -0.48 -1.61 15.65
119916 BRD-K15108141 PC3 1.11 uM 6 h 0.0 0.0 0.0 -0.42 -1.41 2.02
122526 BRD-K15108141 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130603 BRD-K15108141 HA1E 0.74 uM 24 h 0.23 0.96 0.08 0.0 0.0 0.0
130639 BRD-K15108141 HEK293 0.08 uM 24 h 0.25 1.03 0.13 0.0 0.0 0.0
130682 BRD-K15108141 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130724 BRD-K15108141 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130748 BRD-K15108141 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130796 BRD-K15108141 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).