CMap Candidate Details

Structure:
CMap ID: C07163
Pert ID: BRD-K15179879
Compound Name: carfilzomib
Targets: PSMB1; PSMB2; PSMB5; PSMB8; PSMB9; PSMB10
MoA: Proteasome inhibitor
SMILES: CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1
InchiKey: BLMPQMFVWMYDKT-NZTKNTHTSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122274 BRD-K15179879 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122290 BRD-K15179879 A549 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122308 BRD-K15179879 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122404 BRD-K15179879 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122428 BRD-K15179879 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122499 BRD-K15179879 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130643 BRD-K15179879 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130685 BRD-K15179879 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130728 BRD-K15179879 HT29 0.03 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
130751 BRD-K15179879 MCF10A 0.08 uM 24 h -0.28 -1.16 0.45 0.0 0.0 0.0
130822 BRD-K15179879 PC3 0.08 uM 24 h 0.18 0.73 0.0 0.0 0.0 0.0
130849 BRD-K15179879 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).