CMap Candidate Details

Structure:
CMap ID: C00718
Pert ID: BRD-A29009894
Compound Name: AZD-1480
Targets: JAK1; JAK2
MoA: JAK inhibitor
SMILES: CC(Nc1ncc(Cl)c(Nc2cc(C)[nH]n2)n1)c1ncc(F)cn1
InchiKey: PDOQBOJDRPLBQU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91785 BRD-A29009894 HS578T 2.22 uM 6 h 0.0 0.0 0.0 -0.24 -0.81 0.13
91905 BRD-A29009894 MDAMB231 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91922 BRD-A29009894 SKBR3 2.22 uM 24 h -0.26 -1.1 0.34 0.0 0.0 0.0
94423 BRD-A29009894 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94457 BRD-A29009894 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94492 BRD-A29009894 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94564 BRD-A29009894 CD34 0.37 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
94610 BRD-A29009894 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
94652 BRD-A29009894 HEK293 0.04 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.51
94702 BRD-A29009894 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94759 BRD-A29009894 HME1 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
94801 BRD-A29009894 HT29 1.11 uM 24 h -0.29 -1.2 0.56 -0.27 -0.9 0.29
94851 BRD-A29009894 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94901 BRD-A29009894 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94947 BRD-A29009894 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94984 BRD-A29009894 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95029 BRD-A29009894 NEU 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95057 BRD-A29009894 NPC 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.66 0.01
95127 BRD-A29009894 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95177 BRD-A29009894 SHSY5Y 10 uM 24 h 0.29 1.2 0.43 -0.29 -0.97 0.46
95217 BRD-A29009894 SKL 0.37 uM 24 h -0.22 -0.93 0.07 -0.28 -0.94 0.37
95286 BRD-A29009894 THP1 10 uM 24 h -0.26 -1.08 0.29 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).