CMap Candidate Details

Structure:
CMap ID: C00723
Pert ID: BRD-A29322418
Compound Name: potassium-canrenoate
Targets: NR3C2
MoA: Mineralocorticoid receptor antagonist
SMILES: C[C@]12CCC3C(C=CC4=CC(=O)CC[C@]34C)C1CC[C@@]2(O)CCC(O)=O
InchiKey: PBKZPPIHUVSDNM-GMTJQTPWSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5395 BRD-A29322418 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5719 BRD-A29322418 HCC515 10 uM 6 h 0.23 0.96 0.08 0.0 0.0 0.0
5833 BRD-A29322418 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6329 BRD-A29322418 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
39559 BRD-A29322418 ASC 10 uM 24 h 0.18 0.77 0.0 0.0 0.0 0.0
40985 BRD-A29322418 NPC 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.2
41308 BRD-A29322418 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119996 BRD-A29322418 A549 0.37 uM 24 h 0.0 0.0 0.0 0.37 1.31 1.59
120058 BRD-A29322418 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120113 BRD-A29322418 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120155 BRD-A29322418 MCF??7.00 0.37 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
120190 BRD-A29322418 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.2 0.7 0.02
128796 BRD-A29322418 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128878 BRD-A29322418 YAPC 0.25 uM 24 h -0.27 -1.12 0.39 0.21 0.75 0.04
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).