CMap Candidate Details

Structure:
CMap ID: C07243
Pert ID: BRD-K15426076
Compound Name: iguratimod
Targets: PTGS2
MoA: NFKB pathway inhibitor; Cyclooxygenase inhibitor
SMILES: CS(=O)(=O)Nc1cc2occ(NC=O)c(=O)c2cc1Oc1ccccc1
InchiKey: ANMATWQYLIFGOK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122273 BRD-K15426076 A375 10 uM 24 h 0.16 0.67 0.0 -0.29 -0.98 0.49
122289 BRD-K15426076 A549 10 uM 24 h -0.23 -0.94 0.08 -0.32 -1.08 0.8
122307 BRD-K15426076 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.2
122376 BRD-K15426076 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.24
122403 BRD-K15426076 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122498 BRD-K15426076 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122529 BRD-K15426076 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130642 BRD-K15426076 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130684 BRD-K15426076 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130727 BRD-K15426076 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130799 BRD-K15426076 MDAMB231 0.03 uM 24 h -0.32 -1.35 0.98 -0.23 -0.76 0.07
130821 BRD-K15426076 PC3 2.22 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).