CMap Candidate Details

Structure:
CMap ID: C00728
Pert ID: BRD-A29437505
Compound Name: RWJ-21757
Targets: TLR7
MoA: TLR agonist
SMILES: Nc1nc2n(C3OC(CO)C(O)C3O)c(=O)n(CC=C)c2c(=O)[nH]1
InchiKey: VDCRFBBZFHHYGT-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4010 BRD-A29437505 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
4516 BRD-A29437505 HCC515 10 uM 6 h 0.2 0.83 0.0 0.0 0.0 0.0
4739 BRD-A29437505 PC3 10 uM 6 h 0.26 1.07 0.2 -0.28 -0.93 0.36
4986 BRD-A29437505 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37056 BRD-A29437505 A375 10 uM 6 h 0.0 0.0 0.0 -0.4 -1.33 1.84
37223 BRD-A29437505 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37470 BRD-A29437505 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37994 BRD-A29437505 HT29 10 uM 6 h 0.0 0.0 0.0 0.24 0.86 0.15
38255 BRD-A29437505 MCF??7.00 10 uM 6 h -0.29 -1.22 0.6 0.24 0.86 0.16
38320 BRD-A29437505 NPC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.03
38619 BRD-A29437505 PHH 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
38839 BRD-A29437505 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).