CMap Candidate Details

Structure:
CMap ID: C07298
Pert ID: BRD-K15592317
Compound Name: CP-466722
Targets: ATM
MoA: ATM kinase inhibitor
SMILES: COc1cc2ncnc(-n3nc(nc3N)-c3ccccn3)c2cc1OC
InchiKey: ILBRKJBKDGCSCB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
479 BRD-K15592317 BJAB 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
525 BRD-K15592317 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
589 BRD-K15592317 K562 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
617 BRD-K15592317 KMS34 10 uM 24 h 0.0 0.0 0.0 0.38 1.35 1.72
662 BRD-K15592317 MINO 10 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.15
709 BRD-K15592317 NALM6 10 uM 24 h 0.0 0.0 0.0 0.33 1.15 0.9
752 BRD-K15592317 OCILY19 10 uM 24 h 0.22 0.93 0.04 0.0 0.0 0.0
823 BRD-K15592317 OCILY3 10 uM 4 h 0.0 0.0 0.0 0.2 0.71 0.02
850 BRD-K15592317 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
897 BRD-K15592317 THP1 10 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
933 BRD-K15592317 TMD8 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.06
30169 BRD-K15592317 A549 10 uM 6 h -0.29 -1.2 0.57 0.0 0.0 0.0
30374 BRD-K15592317 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
31280 BRD-K15592317 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31689 BRD-K15592317 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32364 BRD-K15592317 NPC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
32740 BRD-K15592317 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32956 BRD-K15592317 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33247 BRD-K15592317 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
91536 BRD-K15592317 BT20 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91642 BRD-K15592317 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
91706 BRD-K15592317 MDAMB231 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.09 0.83
91768 BRD-K15592317 SKBR3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91993 BRD-K15592317 A375 10 uM 24 h 0.32 1.34 0.9 0.0 0.0 0.0
92069 BRD-K15592317 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92103 BRD-K15592317 HCC515 3.33 uM 24 h -0.28 -1.16 0.48 -0.29 -0.98 0.48
92140 BRD-K15592317 HS578T 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92234 BRD-K15592317 MCF10A 10 uM 3 h 0.0 0.0 0.0 -0.37 -1.24 1.29
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).