CMap Candidate Details

Structure:
CMap ID: C07394
Pert ID: BRD-K15916496
Compound Name: clotrimazole
Targets: KCNN4
MoA: Imidazoline ligand; Cytochrome P450 inhibitor
SMILES: Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
InchiKey: VNFPBHJOKIVQEB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25331 BRD-K15916496 VCAP 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.36
51212 BRD-K15916496 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.28
51440 BRD-K15916496 PC3 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.67 0.02
52734 BRD-K15916496 HEPG2 10 uM 24 h 0.27 1.14 0.31 0.0 0.0 0.0
53179 BRD-K15916496 MCF10A 10 uM 24 h -0.17 -0.69 0.0 -0.31 -1.05 0.68
100141 BRD-K15916496 U2OS 10 uM 6 h -0.19 -0.79 0.0 0.24 0.87 0.16
120230 BRD-K15916496 A375 10 uM 24 h 0.21 0.86 0.01 0.19 0.67 0.01
120264 BRD-K15916496 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120303 BRD-K15916496 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120335 BRD-K15916496 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120372 BRD-K15916496 HT29 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.69
120457 BRD-K15916496 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).