CMap Candidate Details

Structure:
CMap ID: C00742
Pert ID: BRD-A29901043
Compound Name: KIN001-127
Targets: ITK
MoA: ITK inhibitor
SMILES: COc1cc(C)c(Sc2cnc(NC(=O)c3ccc(CNC(C)C(C)C)cc3)s2)cc1C(=O)N1CCN(CC1)C(C)=O
InchiKey: RRHONYZEMUNMJX-UHFFFAOYSA-N
Compound Aliases: KIN-001-127

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33547 BRD-A29901043 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34263 BRD-A29901043 HA1E 10 uM 6 h -0.24 -0.98 0.12 0.34 1.19 1.03
34768 BRD-A29901043 HEPG2 10 uM 6 h -0.27 -1.14 0.43 0.29 1.02 0.48
35387 BRD-A29901043 MCF??7.00 10 uM 6 h 0.22 0.94 0.05 0.0 0.0 0.0
36140 BRD-A29901043 PHH 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.2
36434 BRD-A29901043 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36730 BRD-A29901043 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91498 BRD-A29901043 BT20 10 uM 24 h 0.0 0.0 0.0 0.24 0.83 0.12
91595 BRD-A29901043 HS578T 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91677 BRD-A29901043 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91762 BRD-A29901043 SKBR3 10 uM 6 h -0.34 -1.4 1.15 -0.28 -0.95 0.39
94463 BRD-A29901043 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94521 BRD-A29901043 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94572 BRD-A29901043 CD34 10 uM 24 h -0.25 -1.02 0.19 0.0 0.0 0.0
94615 BRD-A29901043 HCC515 10 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.19
94660 BRD-A29901043 HEK293 10 uM 24 h 0.0 0.0 0.0 0.35 1.23 1.19
94708 BRD-A29901043 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94767 BRD-A29901043 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94806 BRD-A29901043 HT29 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.88
94859 BRD-A29901043 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94910 BRD-A29901043 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.38 1.35 1.72
94954 BRD-A29901043 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95037 BRD-A29901043 NEU 0.12 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.4
95063 BRD-A29901043 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95133 BRD-A29901043 PC3 10 uM 24 h -0.17 -0.72 0.0 0.31 1.1 0.69
95186 BRD-A29901043 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95245 BRD-A29901043 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95294 BRD-A29901043 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).