CMap Candidate Details

Structure:
CMap ID: C07575
Pert ID: BRD-K16444452
Compound Name: ibudilast
Targets: PDE10A; MIF; PDE3A; PDE4A; PDE4B; PDE4C; PDE4D; TLR4
MoA: Phosphodiesterase inhibitor; Leukotriene receptor antagonist
SMILES: CC(C)C(=O)c1c(nn2ccccc12)C(C)C
InchiKey: ZJVFLBOZORBYFE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2090 BRD-K16444452 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.8 0.12
2381 BRD-K16444452 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2723 BRD-K16444452 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41916 BRD-K16444452 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42315 BRD-K16444452 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42646 BRD-K16444452 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.83 0.16
43506 BRD-K16444452 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43805 BRD-K16444452 PHH 10 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
44082 BRD-K16444452 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52135 BRD-K16444452 MCF??7.00 10 uM 6 h -0.26 -1.09 0.32 -0.23 -0.78 0.1
90936 BRD-K16444452 HUH7 15 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
100145 BRD-K16444452 U2OS 10 uM 6 h 0.23 0.95 0.06 0.21 0.75 0.04
120236 BRD-K16444452 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120309 BRD-K16444452 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120466 BRD-K16444452 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128924 BRD-K16444452 HELA 0.03 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
128943 BRD-K16444452 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).