CMap Candidate Details

Structure:
CMap ID: C07609
Pert ID: BRD-K16542329
Compound Name: zaprinast
Targets: PDE5A
MoA: Phosphodiesterase inhibitor
SMILES: CCCOc1ccccc1-c1nc2[nH]nnc2c(=O)[nH]1
InchiKey: REZGGXNDEMKIQB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
51279 BRD-K16542329 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91406 BRD-K16542329 HUH7 12.5 uM 72 h -0.31 -1.28 0.77 0.0 0.0 0.0
96779 BRD-K16542329 PC3 10 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
100148 BRD-K16542329 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
120239 BRD-K16542329 A375 10 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
120275 BRD-K16542329 A549 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.05
120312 BRD-K16542329 HA1E 1.11 uM 24 h 0.16 0.68 0.0 0.0 0.0 0.0
120359 BRD-K16542329 HELA 1.11 uM 3 h 0.0 0.0 0.0 -0.24 -0.8 0.12
120470 BRD-K16542329 YAPC 0.37 uM 24 h 0.26 1.07 0.2 0.25 0.9 0.21
128947 BRD-K16542329 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).