CMap Candidate Details

Structure:
CMap ID: C00762
Pert ID: BRD-A30815329
Compound Name: felodipine
Targets: NR3C2; CACNA1C; CACNA1D; CACNA1S
MoA: Calcium channel blocker
SMILES: CCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(Cl)c1Cl)C(=O)OC
InchiKey: RZTAMFZIAATZDJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4291 BRD-A30815329 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4845 BRD-A30815329 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37473 BRD-A30815329 ASC 10 uM 24 h 0.0 0.0 0.0 0.36 1.29 1.49
37803 BRD-A30815329 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38323 BRD-A30815329 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38621 BRD-A30815329 PHH 10 uM 24 h 0.25 1.04 0.15 0.25 0.9 0.22
38841 BRD-A30815329 SKB 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.34
51560 BRD-A30815329 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91068 BRD-A30815329 HUH7 8 uM 72 h 0.0 0.0 0.0 -0.3 -1.03 0.62
121895 BRD-A30815329 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121917 BRD-A30815329 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121958 BRD-A30815329 HEK293 0.37 uM 24 h -0.35 -1.45 1.43 -0.36 -1.22 1.25
122050 BRD-A30815329 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122167 BRD-A30815329 PC3 10 uM 24 h -0.26 -1.09 0.32 0.0 0.0 0.0
122193 BRD-A30815329 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130229 BRD-A30815329 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130290 BRD-A30815329 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.03
130318 BRD-A30815329 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130351 BRD-A30815329 JURKAT 0.01 uM 24 h 0.24 1.0 0.1 0.25 0.87 0.17
130400 BRD-A30815329 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130450 BRD-A30815329 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.84
130522 BRD-A30815329 YAPC 2.22 uM 24 h 0.18 0.76 0.0 -0.26 -0.88 0.25
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).