CMap Candidate Details

Structure:
CMap ID: C00766
Pert ID: BRD-A30984645
Compound Name: GDC-0834
Targets: BTK
MoA: BTK inhibitor
SMILES: CN1CCN(C)C(=O)C1c1ccc(Nc2nc(cn(C)c2=O)-c2cccc(NC(=O)c3cc4CCCCc4s3)c2C)cc1
InchiKey: CDOOFZZILLRUQH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
87318 BRD-A30984645 BJAB 10 uM 6 h 0.0 0.0 0.0 0.3 1.05 0.57
87343 BRD-A30984645 HBL1 10 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
87394 BRD-A30984645 K562 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87441 BRD-A30984645 KMS34 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87516 BRD-A30984645 MINO 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87545 BRD-A30984645 NALM6 10 uM 24 h 0.24 0.98 0.09 0.0 0.0 0.0
87596 BRD-A30984645 OCILY10 10 uM 24 h 0.31 1.29 0.67 0.31 1.08 0.67
87645 BRD-A30984645 OCILY19 2.5 uM 24 h 0.0 0.0 0.0 0.35 1.22 1.15
87697 BRD-A30984645 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.74
87745 BRD-A30984645 SKMEL5 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87816 BRD-A30984645 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87864 BRD-A30984645 TMD8 10 uM 6 h 0.34 1.4 1.02 0.3 1.07 0.63
95488 BRD-A30984645 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95555 BRD-A30984645 MCF??7.00 10 uM 24 h -0.24 -0.99 0.14 -0.19 -0.64 0.01
95705 BRD-A30984645 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
121897 BRD-A30984645 A375 10 uM 24 h -0.23 -0.94 0.08 -0.32 -1.07 0.76
121960 BRD-A30984645 HEK293 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.55
121982 BRD-A30984645 HELA 0.37 uM 24 h -0.26 -1.08 0.3 0.0 0.0 0.0
122053 BRD-A30984645 HUVEC 10 uM 24 h -0.26 -1.09 0.31 0.0 0.0 0.0
122169 BRD-A30984645 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130232 BRD-A30984645 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130320 BRD-A30984645 HT29 0.74 uM 24 h -0.28 -1.16 0.48 0.35 1.23 1.19
130354 BRD-A30984645 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
130403 BRD-A30984645 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.21 0.75 0.04
130452 BRD-A30984645 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130525 BRD-A30984645 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).