CMap Candidate Details

Structure:
CMap ID: C07670
Pert ID: BRD-K16730910
Compound Name: regorafenib
Targets: FGFR1; FGFR2; FLT1; FLT4; FRK; ABL1; KDR; KIT; DDR2; PDGFRA; PDGFRB; MAPK11; RAF1; RET; BRAF; TEK
MoA: KIT inhibitor; RAF inhibitor; FGFR inhibitor; PDGFR inhibitor; VEGFR inhibitor; RET tyrosine kinase inhibitor
SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1
InchiKey: FNHKPVJBJVTLMP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90818 BRD-K16730910 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94461 BRD-K16730910 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94495 BRD-K16730910 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94570 BRD-K16730910 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94658 BRD-K16730910 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94765 BRD-K16730910 HME1 10 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.41
94857 BRD-K16730910 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.84
94907 BRD-K16730910 JURKAT 0.12 uM 24 h 0.0 0.0 0.0 -0.19 -0.64 0.01
95035 BRD-K16730910 NEU 10 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
95061 BRD-K16730910 NPC 3.33 uM 24 h 0.32 1.35 0.93 0.0 0.0 0.0
95131 BRD-K16730910 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95183 BRD-K16730910 SHSY5Y 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95221 BRD-K16730910 SKL 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95292 BRD-K16730910 THP1 3.33 uM 24 h -0.29 -1.19 0.53 0.0 0.0 0.0
95444 BRD-K16730910 U2OS 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
117004 BRD-K16730910 A375 3.33 uM 24 h 0.0 0.0 0.0 0.41 1.45 2.22
117119 BRD-K16730910 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
117171 BRD-K16730910 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117215 BRD-K16730910 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120313 BRD-K16730910 HA1E 10 uM 24 h 0.0 0.0 0.0 0.34 1.22 1.15
120360 BRD-K16730910 HELA 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
120403 BRD-K16730910 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120471 BRD-K16730910 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.22
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).