CMap Candidate Details

Structure:
CMap ID: C00769
Pert ID: BRD-A31095847
Compound Name: mozavaptan
Targets: AVPR1A; AVPR1B; AVPR2
MoA: Vasopressin receptor antagonist
SMILES: CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12
InchiKey: WRNXUQJJCIZICJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96611 BRD-A31095847 A375 3.33 uM 24 h -0.25 -1.03 0.2 0.22 0.79 0.07
96683 BRD-A31095847 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121920 BRD-A31095847 A549 10 uM 24 h 0.3 1.23 0.5 -0.34 -1.16 1.11
121937 BRD-A31095847 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.28
121964 BRD-A31095847 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
121985 BRD-A31095847 HELA 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.68
122013 BRD-A31095847 HT29 10 uM 24 h 0.0 0.0 0.0 0.24 0.87 0.17
122059 BRD-A31095847 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122090 BRD-A31095847 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.43 -1.45 15.35
122113 BRD-A31095847 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
122145 BRD-A31095847 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.13 0.97
122198 BRD-A31095847 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122221 BRD-A31095847 YAPC 10 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
130360 BRD-A31095847 JURKAT 0.08 uM 24 h 0.19 0.78 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).