CMap Candidate Details

Structure:
CMap ID: C07699
Pert ID: BRD-K16803204
Compound Name: filgotinib
Targets: JAK1; JAK2
MoA: JAK inhibitor
SMILES: O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1
InchiKey: RIJLVEAXPNLDTC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90868 BRD-K16803204 MCF10A 10 uM 3 h -0.24 -1.01 0.16 -0.35 -1.18 1.15
95380 BRD-K16803204 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95413 BRD-K16803204 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120244 BRD-K16803204 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120281 BRD-K16803204 A549 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.77
120318 BRD-K16803204 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120344 BRD-K16803204 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120439 BRD-K16803204 PC3 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.26
120477 BRD-K16803204 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128949 BRD-K16803204 HT29 0.03 uM 24 h 0.23 0.95 0.06 0.2 0.69 0.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).