CMap Candidate Details

Structure:
CMap ID: C00775
Pert ID: BRD-A31204924
Compound Name: mitotane
Targets: CYP11A1; CYP11B1
MoA: Anti-neoplastic agent
SMILES: ClC(Cl)C(c1ccc(Cl)cc1)c1ccccc1Cl
InchiKey: JWBOIMRXGHLCPP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5261 BRD-A31204924 HA1E 10 uM 24 h -0.24 -1.01 0.15 0.0 0.0 0.0
5512 BRD-A31204924 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.53
6460 BRD-A31204924 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37476 BRD-A31204924 ASC 10 uM 24 h 0.19 0.78 0.0 0.0 0.0 0.0
37997 BRD-A31204924 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38142 BRD-A31204924 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38326 BRD-A31204924 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38624 BRD-A31204924 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118052 BRD-A31204924 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118096 BRD-A31204924 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118234 BRD-A31204924 HEPG2 0.37 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
118359 BRD-A31204924 PC3 0.125 uM 24 h 0.0 0.0 0.0 0.4 1.4 2.18
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).