CMap Candidate Details

Structure:
CMap ID: C07868
Pert ID: BRD-K17349619
Compound Name: HLI-373
Targets: MDM2
MoA: MDM inhibitor
SMILES: CN(C)CCCNc1c2ccccc2n(C)c2nc(=O)n(C)c(=O)c12
InchiKey: LNRUPMPQQGPSQT-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9062 BRD-K17349619 A375 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.19 1.16
9090 BRD-K17349619 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9376 BRD-K17349619 AGS 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.94 0.39
10039 BRD-K17349619 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10364 BRD-K17349619 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10476 BRD-K17349619 HCT116 10 uM 6 h 0.0 0.0 0.0 0.31 1.11 0.72
10749 BRD-K17349619 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.24 1.31
10955 BRD-K17349619 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11241 BRD-K17349619 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11726 BRD-K17349619 NCIH508 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.78 0.1
12002 BRD-K17349619 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12279 BRD-K17349619 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12567 BRD-K17349619 PC3 10 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.59
12748 BRD-K17349619 SW480 10 uM 6 h 0.19 0.79 0.0 0.0 0.0 0.0
13109 BRD-K17349619 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13229 BRD-K17349619 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13593 BRD-K17349619 VCAP 10 uM 6 h -0.26 -1.06 0.26 -0.27 -0.91 0.31
97251 BRD-K17349619 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).