CMap Candidate Details

Structure:
CMap ID: C07985
Pert ID: BRD-K17743125
Compound Name: belinostat
Targets: HDAC6; HDAC5; HDAC1; HDAC2; HDAC7; HDAC8; HDAC3; HDAC9; HDAC4
MoA: HDAC inhibitor
SMILES: ONC(=O)C=Cc1cccc(c1)S(=O)(=O)Nc1ccccc1
InchiKey: NCNRHFGMJRPRSK-MDZDMXLPSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
32966 BRD-K17743125 SKB 10 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.53
33440 BRD-K17743125 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90823 BRD-K17743125 MCF10A 1.11 uM 24 h -0.17 -0.72 0.0 0.0 0.0 0.0
93686 BRD-K17743125 ASC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93728 BRD-K17743125 CD34 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93803 BRD-K17743125 HCC515 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93853 BRD-K17743125 HEK293 1.11 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.0
93937 BRD-K17743125 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93996 BRD-K17743125 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94038 BRD-K17743125 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94118 BRD-K17743125 NEU 3.33 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
94179 BRD-K17743125 NPC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94198 BRD-K17743125 PC3 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94252 BRD-K17743125 SHSY5Y 1.11 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
94303 BRD-K17743125 SKL 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94347 BRD-K17743125 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97253 BRD-K17743125 HAP1 0.66 uM 24 h 0.16 0.68 0.0 0.0 0.0 0.0
100164 BRD-K17743125 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
120292 BRD-K17743125 A549 1.11 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
120326 BRD-K17743125 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
120353 BRD-K17743125 HELA 0.37 uM 24 h 0.25 1.04 0.15 0.0 0.0 0.0
120386 BRD-K17743125 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.18 0.65 0.01
120416 BRD-K17743125 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.17
120492 BRD-K17743125 YAPC 0.37 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.65
128894 BRD-K17743125 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).