CMap Candidate Details

Structure:
CMap ID: C00080
Pert ID: BRD-A02990301
Compound Name: lofexidine
Targets: ADRA2A
MoA: Adrenergic receptor agonist
SMILES: CC(Oc1c(Cl)cccc1Cl)C1=NCCN1
InchiKey: KSMAGQUYOIHWFS-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
22624 BRD-A02990301 HCC515 10 uM 6 h -0.18 -0.73 0.0 0.0 0.0 0.0
22905 BRD-A02990301 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.31 1.11 0.72
24251 BRD-A02990301 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.81 0.13
91232 BRD-A02990301 HUH7 12.5 uM 72 h 0.22 0.94 0.05 0.32 1.14 0.86
122838 BRD-A02990301 A375 1.11 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
122911 BRD-A02990301 HEK293 1.11 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.2
122949 BRD-A02990301 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122985 BRD-A02990301 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123036 BRD-A02990301 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123126 BRD-A02990301 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.77
123153 BRD-A02990301 PC3 0.37 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
123198 BRD-A02990301 THP1 0.37 uM 24 h -0.29 -1.2 0.56 0.0 0.0 0.0
123219 BRD-A02990301 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131254 BRD-A02990301 A549 0.74 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.56
131288 BRD-A02990301 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131374 BRD-A02990301 HUVEC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131411 BRD-A02990301 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 -0.2 -0.69 0.02
131446 BRD-A02990301 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).