CMap Candidate Details

Structure:
CMap ID: C08034
Pert ID: BRD-K17894950
Compound Name: indirubin
Targets: CDK5; GSK3A; CDK1
MoA: CDK inhibitor; GSK-3 inhibitor
SMILES: O=C1Nc2ccccc2C1=C1Nc2ccccc2C1=O
InchiKey: CRDNMYFJWFXOCH-YPKPFQOOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
7630 BRD-K17894950 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.19 1.15
7841 BRD-K17894950 HT29 10 uM 24 h 0.0 0.0 0.0 -0.21 -0.71 0.03
8650 BRD-K17894950 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53227 BRD-K17894950 MCF10A 30 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
95312 BRD-K17894950 A549 0.12 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
95346 BRD-K17894950 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
95454 BRD-K17894950 U2OS 0.12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96439 BRD-K17894950 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96506 BRD-K17894950 PC3 10 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.52
120494 BRD-K17894950 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128910 BRD-K17894950 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128930 BRD-K17894950 HELA 0.74 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).