CMap Candidate Details

Structure:
CMap ID: C00817
Pert ID: BRD-A33168282
Compound Name: sotalol
Targets: ADRB1; ADRB2; KCNH2
MoA: Adrenergic receptor antagonist
SMILES: CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1
InchiKey: ZBMZVLHSJCTVON-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6632 BRD-A33168282 A375 10 uM 24 h -0.25 -1.02 0.18 0.0 0.0 0.0
7217 BRD-A33168282 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7524 BRD-A33168282 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7941 BRD-A33168282 HT29 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.0 0.52
25470 BRD-A33168282 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.79 0.11
91089 BRD-A33168282 HUH7 12 uM 72 h -0.18 -0.77 0.0 0.0 0.0 0.0
120558 BRD-A33168282 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120621 BRD-A33168282 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120711 BRD-A33168282 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120755 BRD-A33168282 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120779 BRD-A33168282 PC3 10 uM 24 h 0.0 0.0 0.0 0.43 1.52 2.29
120819 BRD-A33168282 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.28
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).