CMap Candidate Details

Structure:
CMap ID: C00818
Pert ID: BRD-A33280134
Compound Name: etoposide
Targets: TOP2A; TOP2B
MoA: Topoisomerase inhibitor
SMILES: COc1cc(cc(OC)c1O)[C@H]1[C@@H]2C(COC2=O)C(OC2O[C@@H]3COC(C)O[C@H]3[C@H](O)[C@H]2O)c2cc3OCOc3cc12
InchiKey: VJJPUSNTGOMMGY-GEGAHKOSSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90836 BRD-A33280134 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122612 BRD-A33280134 HA1E 1.11 uM 24 h -0.19 -0.79 0.0 0.0 0.0 0.0
122649 BRD-A33280134 HEK293 1.11 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.88
122760 BRD-A33280134 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122780 BRD-A33280134 MDAMB231 10 uM 24 h 0.25 1.06 0.19 0.0 0.0 0.0
122805 BRD-A33280134 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122826 BRD-A33280134 YAPC 10 uM 24 h 0.25 1.03 0.13 0.0 0.0 0.0
130877 BRD-A33280134 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130893 BRD-A33280134 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130984 BRD-A33280134 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131011 BRD-A33280134 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131066 BRD-A33280134 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).