CMap Candidate Details

Structure:
CMap ID: C08292
Pert ID: BRD-K18678457
Compound Name: ZD-7288
Targets: HCN4; HCN1; HCN3; HCN2
MoA: HCN channel blocker
SMILES: CCN(c1ccccc1)c1cc(NC)[n+](C)c(C)n1
InchiKey: JABSKGQQWUDVRU-UHFFFAOYSA-O
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3152 BRD-K18678457 HCC515 10 uM 24 h -0.28 -1.19 0.52 0.37 1.3 1.58
3737 BRD-K18678457 VCAP 10 uM 24 h 0.26 1.07 0.2 0.0 0.0 0.0
44682 BRD-K18678457 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44887 BRD-K18678457 ASC 10 uM 24 h -0.2 -0.85 0.01 0.19 0.68 0.01
45190 BRD-K18678457 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46005 BRD-K18678457 NPC 10 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
46323 BRD-K18678457 PHH 10 uM 24 h -0.24 -1.02 0.18 0.2 0.72 0.02
46638 BRD-K18678457 SKB 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
120258 BRD-K18678457 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120331 BRD-K18678457 HA1E 0.125 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
120370 BRD-K18678457 HELA 10 uM 3 h 0.0 0.0 0.0 0.31 1.08 0.66
120390 BRD-K18678457 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120427 BRD-K18678457 MCF??7.00 3.33 uM 24 h -0.19 -0.78 0.0 0.24 0.85 0.15
120451 BRD-K18678457 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.81
120506 BRD-K18678457 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).