CMap Candidate Details

Structure:
CMap ID: C08331
Pert ID: BRD-K18787491
Compound Name: U-0126
Targets: MAP2K1; MAP2K2
MoA: MEK inhibitor
SMILES: NC(Sc1ccccc1N)=C(C#N)/C(C#N)=C(N)Sc1ccccc1N
InchiKey: DVEXZJFMOKTQEZ-JYFOCSDGSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2847 BRD-K18787491 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3153 BRD-K18787491 HCC515 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.71
3601 BRD-K18787491 PC3 10 uM 6 h -0.26 -1.08 0.3 0.0 0.0 0.0
3738 BRD-K18787491 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.21
44332 BRD-K18787491 A375 10 uM 6 h 0.0 0.0 0.0 0.41 1.46 2.23
44889 BRD-K18787491 ASC 10 uM 24 h -0.25 -1.06 0.25 0.0 0.0 0.0
45459 BRD-K18787491 HT29 10 uM 6 h 0.2 0.81 0.0 0.0 0.0 0.0
45667 BRD-K18787491 MCF??7.00 10 uM 24 h 0.27 1.14 0.31 0.0 0.0 0.0
46007 BRD-K18787491 NPC 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
46640 BRD-K18787491 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53438 BRD-K18787491 HEPG2 3.33 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
53502 BRD-K18787491 HUH7 12.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53717 BRD-K18787491 PHH 3.33 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87308 BRD-K18787491 BJAB 10 uM 3 h 0.28 1.16 0.35 0.0 0.0 0.0
87371 BRD-K18787491 HBL1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87421 BRD-K18787491 K562 10 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.61
87468 BRD-K18787491 KMS34 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.65
87529 BRD-K18787491 MINO 10 uM 6 h 0.29 1.2 0.42 -0.26 -0.87 0.22
87573 BRD-K18787491 NALM6 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
87623 BRD-K18787491 OCILY10 2.5 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
87673 BRD-K18787491 OCILY19 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87724 BRD-K18787491 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.2 0.73 0.03
87772 BRD-K18787491 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.83
87806 BRD-K18787491 THP1 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
87855 BRD-K18787491 TMD8 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
96120 BRD-K18787491 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99726 BRD-K18787491 U2OS 12.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).