CMap Candidate Details

Structure:
CMap ID: C08352
Pert ID: BRD-K18855837
Compound Name: varenicline
Targets: CHRNA4
MoA: Acetylcholine receptor agonist
SMILES: C1[C@H]2CNC[C@@H]1c1cc3nccnc3cc21
InchiKey: JQSHBVHOMNKWFT-DTORHVGOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1460 BRD-K18855837 NPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25804 BRD-K18855837 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25913 BRD-K18855837 A549 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.82
26294 BRD-K18855837 ASC 10 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
26629 BRD-K18855837 HA1E 10 uM 6 h 0.21 0.86 0.01 0.0 0.0 0.0
26941 BRD-K18855837 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.96 0.42
27252 BRD-K18855837 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
27523 BRD-K18855837 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
27875 BRD-K18855837 NEU 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
28458 BRD-K18855837 PC3 10 uM 24 h 0.26 1.08 0.2 0.0 0.0 0.0
28824 BRD-K18855837 PHH 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.68 0.02
29145 BRD-K18855837 SKB 10 uM 24 h 0.28 1.15 0.32 0.0 0.0 0.0
29616 BRD-K18855837 VCAP 10 uM 6 h -0.2 -0.84 0.01 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).