CMap Candidate Details

Structure:
CMap ID: C00836
Pert ID: BRD-A34255068
Compound Name: rolipram
Targets: PDE4A; PDE4B; PDE4C; PDE4D
MoA: Phosphodiesterase inhibitor
SMILES: COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
InchiKey: HJORMJIFDVBMOB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1423 BRD-A34255068 NPC 1.25 uM 24 h 0.18 0.77 0.0 0.0 0.0 0.0
5721 BRD-A34255068 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9588 BRD-A34255068 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10664 BRD-A34255068 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.01 0.58
11336 BRD-A34255068 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.27 0.97 0.35
11905 BRD-A34255068 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12202 BRD-A34255068 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25471 BRD-A34255068 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46195 BRD-A34255068 PHH 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
46511 BRD-A34255068 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91379 BRD-A34255068 HUH7 12 uM 72 h 0.28 1.15 0.32 0.0 0.0 0.0
95831 BRD-A34255068 A549 1.11 uM 6 h 0.19 0.78 0.0 0.0 0.0 0.0
95891 BRD-A34255068 YAPC 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
121911 BRD-A34255068 A375 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
121972 BRD-A34255068 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122026 BRD-A34255068 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122078 BRD-A34255068 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122096 BRD-A34255068 MCF10A 1.11 uM 24 h 0.31 1.3 0.73 -0.37 -1.24 1.35
122125 BRD-A34255068 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
130246 BRD-A34255068 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130306 BRD-A34255068 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130466 BRD-A34255068 MDAMB231 2.22 uM 24 h 0.27 1.13 0.3 0.0 0.0 0.0
130486 BRD-A34255068 PC3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130509 BRD-A34255068 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).