CMap Candidate Details

Structure:
CMap ID: C08364
Pert ID: BRD-K18895904
Compound Name: olanzapine
Targets: DRD1; DRD2; DRD3; DRD4; HRH1; HTR1A; HTR1B; HTR1D; HTR1E; HTR2A; HTR2C; HTR6; HTR7
MoA: Dopamine receptor antagonist; Serotonin receptor antagonist
SMILES: CN1CCN(CC1)C1=Nc2ccccc2Nc2sc(C)cc12
InchiKey: KVWDHTXUZHCGIO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1437 BRD-K18895904 NPC 12.5 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
24560 BRD-K18895904 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25335 BRD-K18895904 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91121 BRD-K18895904 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
121379 BRD-K18895904 HA1E 10 uM 24 h -0.22 -0.92 0.06 -0.25 -0.86 0.21
121472 BRD-K18895904 PC3 0.04 uM 24 h -0.28 -1.15 0.44 0.0 0.0 0.0
121492 BRD-K18895904 YAPC 0.125 uM 24 h 0.31 1.29 0.67 -0.31 -1.03 0.62
129394 BRD-K18895904 A375 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129457 BRD-K18895904 HELA 0.03 uM 24 h 0.27 1.14 0.31 0.35 1.24 1.25
129479 BRD-K18895904 HT29 0.74 uM 24 h 0.36 1.49 1.16 0.21 0.76 0.05
129506 BRD-K18895904 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.34 1.22 1.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).