CMap Candidate Details

Structure:
CMap ID: C08367
Pert ID: BRD-K18910433
Compound Name: estradiol
Targets: ESR1; ESR2; NR1I2
MoA: Estrogen receptor agonist
SMILES: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CC[C@@H]2O
InchiKey: VOXZDWNPVJITMN-ZBRFXRBCSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4556 BRD-K18910433 HCC515 10 uM 6 h 0.21 0.86 0.01 0.4 1.42 2.2
37608 BRD-K18910433 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38921 BRD-K18910433 SKB 10 uM 24 h -0.24 -1.02 0.18 -0.25 -0.84 0.17
52360 BRD-K18910433 HA1E 10 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.07
52450 BRD-K18910433 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52556 BRD-K18910433 HEPG2 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53070 BRD-K18910433 MCF10A 100 uM 24 h -0.23 -0.94 0.08 -0.51 -1.72 15.65
90296 BRD-K18910433 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90647 BRD-K18910433 HCT116 3.33 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.91
91279 BRD-K18910433 HUH7 12 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
97702 BRD-K18910433 NKDBA 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
97825 BRD-K18910433 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.99 0.5
98797 BRD-K18910433 NPC 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
98871 BRD-K18910433 NEU 10 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
104629 BRD-K18910433 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
119394 BRD-K18910433 A375 10 uM 24 h 0.25 1.05 0.17 0.0 0.0 0.0
119426 BRD-K18910433 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119563 BRD-K18910433 HT29 10 uM 24 h -0.16 -0.68 0.0 -0.33 -1.1 0.87
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).