CMap Candidate Details

Structure:
CMap ID: C08425
Pert ID: BRD-K19061412
Compound Name: mubritinib
Targets: ERBB2
MoA: Receptor tyrosine protein kinase inhibitor
SMILES: FC(F)(F)c1ccc(C=Cc2nc(COc3ccc(CCCCn4ccnn4)cc3)co2)cc1
InchiKey: ZTFBIUXIQYRUNT-MDWZMJQESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121357 BRD-K19061412 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121494 BRD-K19061412 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129424 BRD-K19061412 HA1E 0.08 uM 24 h 0.0 0.0 0.0 0.3 1.08 0.65
129459 BRD-K19061412 HELA 0.01 uM 24 h -0.28 -1.16 0.46 -0.2 -0.67 0.02
129481 BRD-K19061412 HT29 0.25 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
129508 BRD-K19061412 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129545 BRD-K19061412 PC3 0.25 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).