CMap Candidate Details

Structure:
CMap ID: C08430
Pert ID: BRD-K19085898
Compound Name: darapladib
Targets: PLA2G7
MoA: Phospholipase inhibitor
SMILES: CCN(CC)CCN(Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)C(=O)Cn1c2CCCc2c(=O)nc1SCc1ccc(F)cc1
InchiKey: WDPFJWLDPVQCAJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121433 BRD-K19085898 HT29 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.93
121474 BRD-K19085898 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121497 BRD-K19085898 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129395 BRD-K19085898 A375 2.22 uM 24 h 0.33 1.38 0.97 0.27 0.96 0.33
129426 BRD-K19085898 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129460 BRD-K19085898 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129511 BRD-K19085898 MCF??7.00 0.74 uM 24 h -0.2 -0.82 0.0 -0.44 -1.49 15.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).