CMap Candidate Details

Structure:
CMap ID: C08477
Pert ID: BRD-K19220233
Compound Name: JNK-9L
Targets: MAPK8
MoA: JNK inhibitor
SMILES: N#Cc1cc(cc(c1)-c1ccnc(Nc2ccc(cc2)-n2cnc(n2)-c2cccnc2)n1)N1CCOCC1
InchiKey: VCUNSUCAAIMDKU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33894 BRD-K19220233 A549 10 uM 6 h -0.28 -1.18 0.5 0.0 0.0 0.0
34058 BRD-K19220233 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34574 BRD-K19220233 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34844 BRD-K19220233 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.24 0.84 0.13
35743 BRD-K19220233 NPC 10 uM 24 h 0.24 1.0 0.11 -0.25 -0.83 0.17
36511 BRD-K19220233 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36953 BRD-K19220233 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91875 BRD-K19220233 MCF??7.00 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91890 BRD-K19220233 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
92414 BRD-K19220233 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92474 BRD-K19220233 BT20 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92507 BRD-K19220233 HA1E 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92541 BRD-K19220233 HME1 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92588 BRD-K19220233 HS578T 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92635 BRD-K19220233 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92679 BRD-K19220233 LNCAP 0.12 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.21
92715 BRD-K19220233 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
92812 BRD-K19220233 PC3 0.37 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.66
92834 BRD-K19220233 SKBR3 1.11 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).